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Hunan Yunbang Pharmaceutical Co., Ltd. (Yunbangpharm) located in Changsha High-tech Industrial Park, Hunan. It is a high-tech enterprise specializing in the research and development, production and sales of Pharmaceutical raw materials, Pharmaceutical intermediates(API) and Fine chemicals. Based in China, Yunbangpharm has been providing suitable solutions for many domestic,foreign pharmaceutical companies and traders. Excellent quality, good reputation and authentic price have won the praise of the majority of customers.
The company adheres to the corporate tenet of "We do not produce medicines, but help pharmaceutical companies make good medicines".Acetylcholinesterase is an enzyme that plays a crucial role in the termination of neurotransmission at cholinergic synapses in the nervous system. It belongs to the family of cholinesterases and is primarily found at cholinergic nerve endings and neuromuscular junctions.
The primary function of acetylcholinesterase is to hydrolyze the neurotransmitter acetylcholine, rapidly breaking it down into choline and acetate. This enzymatic activity is essential for the swift termination of cholinergic signaling, allowing for proper neuronal communication and the prevention of excessive stimulation.
By cleaving acetylcholine, acetylcholinesterase regulates the duration and intensity of cholinergic signaling, ensuring that the neurotransmitter is not overly prolonged in its action. This is crucial for the proper functioning of neuromuscular junctions, as well as for cognitive processes, memory, and various autonomic functions mediated by cholinergic neurotransmission.
The activity of acetylcholinesterase is also targeted by certain drugs and toxins, such as organophosphate and carbamate compounds, which inhibit the enzyme and lead to an accumulation of acetylcholine. This can result in prolonged cholinergic effects, leading to symptoms such as muscle weakness, respiratory depression, and other manifestations of cholinergic overstimulation.
In addition to its physiological role, acetylcholinesterase is of interest in the field of pharmacology and toxicology, particularly in the context of organophosphate and carbamate poisoning, as well as in the development of medications for conditions such as Alzheimer's disease.
In summary, acetylcholinesterase is a vital enzyme involved in the hydrolysis of acetylcholine, regulating cholinergic neurotransmission and ensuring the proper termination of cholinergic signaling. Its activity is essential for normal neuromuscular and cognitive function, and its modulation is of clinical significance in various pharmacological and toxicological contexts.
1:Can I get some samples before bulk order?
A: Most products provide free samples, but the shipping cost be paid by customers.
2: What's your MOQ?
A: We can have a discussion.
3: Which kind of payment terms do you accept?
A: PI will be sent first after confirmation of order,enclosed our bank information.Payment by T/T, Western Union,D/P, ETC.
4.How to place an order?
A: You can contact me through Trademanager, WhatsApp, Email and other contact methods, tell me the product and quantity you need, and then we will give you a quote.
5:How about your delivery time?
A: Generally, it will take 3 to 5 days after receiving your advance payment.
6:How do you treat quality complaint?
A: First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.
1. 90days quality guarantee for exchange.
2. For each batch order extracts, we will attach a factory Inspection Report with the goods delivery , including the BatchNo/ Date/ Test index ects; also will keep the archived extracts to ensure received by customers are the same each time.
3. Our team of experienced professionals are available online 24 hours a day to answer any questions and provide guidance on product usage and maintenance.
| Product Name: | Anticholinesterase |
| Synonyms: | Esterase, acetyl choline;TRUE CHOLINESTERASE;TRUE CHOLINESTERASE HUMAN;TRUE CHOLINESTERASE TYPE VI-S;TRUE CHOLINESTERASE TYPE V-S;TRUE CHOLINESTERASE TYPE XII-S;ACETYLCHOLINESTERASE TYPE III ELECTRIC;ACETYLCHOLINE ESTERASE F. ELECTROPHORUS ELECT., ~850 U/MG |
| CAS: | 9000-81-1 |
| MF: | NULL |
| MW: | 0 |
| EINECS: | 232-559-3 |
| Product Categories: | |
| Mol File: | Mol File |
| Anticholinesterase Chemical Properties |
| storage temp. | -20°C |
| solubility | H2O: 1 mg/mL |
| form | powder |
| color | slightly yellow |
| Hazard Codes | B |
| WGK Germany | 3 |
| F | 10-21 |
| Toxicity | The inhibition of AChE by these anticholinesterases leads to an accumulation of endogenous ACh, and thus results in hyperactivation of cholinergic receptors. Signs of acute poisoning can include irritability, tremors, convulsions, and predominately parasympathetic effects, with death usually the result of respiratory failure. Since AChE is contained in erythrocytes, the assay of erythrocyte AChE activity can be used as a diagnostic tool to assess exposure to organophosphorus anticholinesterases. |
| Uses | Pesticides. |
| Uses | Acetylcholinesterase from Electrophorus electricus (electric eel) has been used:
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| Uses | Acetylcholinesterase (AChE) from Sigma has been used in the structure-activity study of phosphoramido acid esters as inhibitors of AChE. |
| Definition | Any substance that inhibits or inactivates acetylcholinesterase, thereby preventing the hydrolysis of acetylcholine. Their action leads to an accumulation of endogenous acetylcholine with a resultant hyperactivity of cholinergic neurons, which can prove lethal. |
| General Description | Predominantly exists as a tetrameric glycoprotein composed of disulfide-linked homodimers with a monomer MW of ~80 kDa. |
| Hazard | Tremors; convulsions; respiratory failure; death. |
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