CAS No: | 53-19-0 |
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Rumus: | C14h10cl4 |
EINECS: | 200-166-6 |
Tipe: | Peralihan Farmasi |
Tampilan: | Bubuk |
Kualitas: | Bidang Teknik |
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Product Name: Mitotan
Synonyms: LYSODREN;2-(2-CHLOROPHENYL)-2-(4-CHLOROPHENYL)-1,1-DICHLOROETHA NE;2,2-(2-chlorophenyl)-2-(4-chlorophenyl)-1,1-dichloroetha ne;2,4'-TDE;2,4'-DDD;(2,4'-DICHLORODIPHENYL)DICHLOROETHA NE;1,1-DICHLORO-2-(O-CHLOROPHENYL)-2-(P-CHLOROPHENYL)ETHA NE;1,1-DICHLORO-2-(2-CHLOROPHENYL)-2-(4-CHLOROPHENYL)ETHA NE
CAS: 53-19-0
MF: C14H10Cl4
MW: 320.04
EINECS: 200-166-6
Melting point: 77-78 °C(lit.)
Boiling point: 405.59°C
Density: 1.3118
Storage temp.: Inert atmosphere,Room Temperature
Appearance: White powder
Description:
Mitotane is an inhibitor of steroidogenesis that suppresses the growth of adrenocortical cells. It blocks the expression of several genes that encode proteins involved in steroidogenesis and disrupts mitochondrial respiratory chain activity in human adrenocortical cells. Mitotane has anti-neoplastic actions, alone or in combination with other compounds, and suppresses cortisol synthesis, although it also has significant toxicity in the gastrointestinal tract and nervous system. It is effective against adrenocortical carcinoma and Cushing's Syndrome in clinical trials.
Uses:
Mitotane is an inhibitor of steroidogenesis that suppresses the growth of adrenocortical cells. It blocks the expression of several genes that encode proteins involved in steroidogenesis and disrupts mitochondrial respiratory chain activity in human adrenocortical cells. Mitotane has anti-neoplastic actions, alone or in combination with other compounds, and suppresses cortisol synthesis, although it also has significant toxicity in the gastrointestinal tract and nervous system. It is effective against adrenocortical carcinoma and Cushing's Syndrome in clinical trials.
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